Abstract
Iron deficiency anemia still remains problematic worldwide. Iron deficiency without anemia is often undiagnosed. We reviewed, in this study, symptoms and syndromes associated with iron deficiency with or without anemia: fatigue, cognitive functions, restless legs syndrome, hair loss, and chronic heart failure. Iron is absorbed through the digestive tract. Hepcidin and ferroportin are the main proteins of iron regulation. Pathogenic micro-organisms or intestinal dysbiosis are suspected to influence iron absorption.
Keywords:
Anémie ferriprive; Carence en fer; Fatigue; Iron deficiency; Iron deficiency anemia; Metabolism; Microbiota; Microbiote; Métabolisme.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Alopecia / etiology
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Anemia, Iron-Deficiency / epidemiology
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Anemia, Iron-Deficiency / etiology
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Animals
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Cation Transport Proteins / physiology
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Cognition Disorders / etiology
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Exercise Tolerance
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Fatigue / etiology
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Heart Failure / etiology
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Humans
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Inflammatory Bowel Diseases / complications
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Inflammatory Bowel Diseases / metabolism
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Inflammatory Bowel Diseases / microbiology
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Intestinal Absorption*
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Intestinal Diseases / complications
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Intestinal Diseases / metabolism*
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Intestinal Diseases / microbiology
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Intestines / microbiology
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Iron Deficiencies*
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Iron, Dietary / pharmacokinetics*
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Malabsorption Syndromes / complications
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Mammals / metabolism
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Microbiota
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Restless Legs Syndrome / etiology
Substances
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Cation Transport Proteins
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Iron, Dietary
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metal transporting protein 1