T-cell antigen receptors: fact and artefact

J F Miller; G Morahan; I D Walker

doi:10.1016/0167-5699(83)90067-1

T-cell antigen receptors: fact and artefact

Immunol Today. 1983 May;4(5):141-3. doi: 10.1016/0167-5699(83)90067-1.

Authors

J F Miller¹, G Morahan, I D Walker

Affiliation

¹ The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia.

PMID: 25291672
DOI: 10.1016/0167-5699(83)90067-1

Abstract

Much has been written to support the view that T-cell antigen-recognition molecules share idiotypes with immunoglobulin and are encoded in the same VH genes. Here Jacques Miller and his colleagues disbute this view and argue instead, from recent evidence, that the genes for T-cell receptors are entirely different from Ig genes.