Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation

Macromol Biosci. 2015 Mar;15(3):342-50. doi: 10.1002/mabi.201400238. Epub 2014 Oct 21.

Abstract

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.

Keywords: biodegradable; blending; drug delivery system; hydrogel; poly(anhydride-esters).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anhydrides / chemistry*
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Cell Death / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Elastic Modulus / drug effects
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Hydrolysis
  • Inflammation / drug therapy*
  • Mice
  • Polyesters / chemistry*
  • Povidone / chemistry*
  • Rheology / drug effects
  • Salicylic Acid / pharmacology
  • Salicylic Acid / therapeutic use*
  • Transition Temperature
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anhydrides
  • Anti-Inflammatory Agents
  • Polyesters
  • Tumor Necrosis Factor-alpha
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Povidone
  • Salicylic Acid