Abstract
Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.
Keywords:
biodegradable; blending; drug delivery system; hydrogel; poly(anhydride-esters).
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anhydrides / chemistry*
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Cell Death / drug effects
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Elastic Modulus / drug effects
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Humans
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Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
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Hydrolysis
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Inflammation / drug therapy*
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Mice
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Polyesters / chemistry*
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Povidone / chemistry*
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Rheology / drug effects
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Salicylic Acid / pharmacology
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Salicylic Acid / therapeutic use*
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Transition Temperature
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anhydrides
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Anti-Inflammatory Agents
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Polyesters
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Tumor Necrosis Factor-alpha
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Povidone
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Salicylic Acid