[Eccrine porocarcinoma with Bowenoid changes: a challenging diagnosis of adnexal neoplasm]

Abstract

Eccrine porocarcinoma is a rare malignant sweat gland tumor, representing less than 0.01% of all cutaneous neoplasms, with eccrin differentiation. Its acrosynringeal origin and physiopathology still remain discussed. The prognosis of this carcinoma is held to be poor with a significant risk of lymph node metastasis and local recurrence. Also, this not specific tumor can be a challenging histological diagnosis, in particular, in Bowenoid variant. We report a case of Bowenoid and keratinizing variant of eccrine porocarcinoma of the left ring finger with pejorative evolution and initial diagnosis of infiltrating squamous cell carcinoma arising in Bowen's disease. The knowledge of these patterns and identification of eccrine differentiation of the tumor are essential for the diagnosis and for adapted therapeutic care.

Keywords: Bowen's disease; Bowenoid variant; Carcinome épidermoïde; Eccrine porocarcinoma; Immunochemistry; Immunohistochimie; Maladie de Bowen; Porocarcinome eccrine; Squamous cell carcinoma; Variant bowénoïde.