Imaging phenotypes in multiple sclerosis

Stefan Dirk Roosendaal; Frederik Barkhof

doi:10.1016/j.nic.2014.09.008

Imaging phenotypes in multiple sclerosis

Neuroimaging Clin N Am. 2015 Feb;25(1):83-96. doi: 10.1016/j.nic.2014.09.008. Epub 2014 Oct 7.

Authors

Stefan Dirk Roosendaal¹, Frederik Barkhof²

Affiliations

¹ Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands. Electronic address: stefanmed@yahoo.com.
² Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, PO Box 7057, Amsterdam, 1007 MB, The Netherlands.

PMID: 25476514
DOI: 10.1016/j.nic.2014.09.008

Abstract

Multiple sclerosis (MS) is a common disease of the central nervous system, with various clinical symptoms and a heterogeneous disease course. MRI can depict focal and diffuse manifestations of the disease, and accurately measure progression over time. The precise pathogenesis of MS is unknown. Nevertheless, genetic influences have been found for susceptibility to MS in linkage and association studies. More recent genome-wide association studies have revealed other genes to be related to disease susceptibility and severity, explaining part of the variability in symptoms, radiological manifestations and disease course. Studies relating genetics and imaging in MS are discussed in this paper.

Keywords: Genetics; Imaging; MR imaging; Multiple sclerosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diagnostic Imaging / methods*
Humans
Magnetic Resonance Imaging / methods
Multiple Sclerosis / diagnosis*
Multiple Sclerosis / genetics*
Phenotype