Abstract
We describe a case of a tumour of the sigmoid colon with hepatic metastases in a patient with previously documented ulcerative colitis. A diagnosis of metastatic vipoma was made on the basis of high plasma levels of vasoactive intestinal polypeptide (VIP). Profuse diarrhoea and profound metabolic upset were corrected by the use of a somatostatin analogue SMS 201-995, whilst conventional cytotoxic therapy produced a significant tumour response with return of the plasma VIP level to normal.
MeSH terms
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Adenoma, Islet Cell / secondary*
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Colitis, Ulcerative / blood
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Colitis, Ulcerative / pathology
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Colostomy
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Combined Modality Therapy
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Female
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Humans
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Liver Neoplasms / blood
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Liver Neoplasms / pathology
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Liver Neoplasms / secondary
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Liver Neoplasms / therapy
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Octreotide / administration & dosage
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Pancreatic Neoplasms / blood
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Pancreatic Neoplasms / pathology
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Pancreatic Neoplasms / secondary*
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Pancreatic Neoplasms / therapy
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Sigmoid Neoplasms / blood
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Sigmoid Neoplasms / pathology*
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Sigmoid Neoplasms / therapy
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Streptozocin / administration & dosage
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Vasoactive Intestinal Peptide / blood
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Vipoma / blood
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Vipoma / pathology
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Vipoma / secondary*
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Vipoma / therapy
Substances
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Vasoactive Intestinal Peptide
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Streptozocin
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Octreotide