1 Keenan Research Centre and Critical Care Department, St Michael's Hospital, Toronto, ON, Canada; and, Département de Réanimation Médicale et Médecine Hyperbare, LUNAM, Université d'Angers, CHU d'Angers, Angers, France Keenan Research Centre and Critical Care Department, St Michael's Hospital; and, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.