Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades

Annelies Nijdam; Carmen Altisent; Manuel D Carcao; Ana R Cid; Ségolène Claeyssens-Donadel; Karin Kurnik; Rolf Ljung; Beatrice Nolan; Pia Petrini; Helen Platokouki; Anne Rafowicz; Angela E Thomas; Kathelijn Fischer; PedNet and CANAL study groups

doi:10.3324/haematol.2014.115709

Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades

Haematologica. 2015 Mar;100(3):e84-6. doi: 10.3324/haematol.2014.115709. Epub 2014 Dec 19.

Affiliations

¹ Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands.
² Unitat Hemofilia Hospital Vall d'Hebron, Barcelona, Spain.
³ Division of Haematology/Oncology, Department of Paediatrics and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ Unidad de Hemostasia y Trombosis, Hospital Universitario la Fe, Valencia, Spain.
⁵ CHU Purpan Centre de traitement des hémophiles, Toulouse, France.
⁶ Dr. von Haunersches Children's Hospital, University of Munich, Germany.
⁷ Lund University, Department of Clinical Sciences Lund -Paediatrics and Malmö Haemostasis & Thrombosis Centre, Skåne University Hospital, Malmö, Sweden.
⁸ Department of Haematology Oncology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
⁹ Paediatric Department of Coagulation Disorders, Karolinska University Hospital, Stockholm, Sweden.
¹⁰ St. Sophia Children's Hospital, Haemophilia-Haemostasis Unit, Athens, Greece.
¹¹ Centre Régional de Traitement de l'Hémophilie et Autres Maladies Hémorragiques, Centre Hospitalier Universitaire de Bicêtre, Paris, France.
¹² Department of Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland.
¹³ Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands k.fischer@umcutrecht.nl.

No abstract available

Keywords: bleeding; prophylaxis.

Publication types

Historical Article
Letter

MeSH terms

Child, Preschool
Cohort Studies
Factor VIII / history
Factor VIII / therapeutic use*
Female
Hemarthrosis / blood
Hemarthrosis / mortality
Hemarthrosis / pathology
Hemarthrosis / prevention & control*
Hemophilia A / blood
Hemophilia A / drug therapy*
Hemophilia A / mortality
Hemophilia A / pathology
History, 20th Century
History, 21st Century
Humans
Infant
Injections, Intravenous
Joints / blood supply
Joints / drug effects*
Joints / pathology
Male
Survival Analysis
Time-to-Treatment

Substances

Factor VIII