The murine Il-6 gene maps to the proximal region of chromosome 5

J Immunol. 1989 Feb 15;142(4):1372-6.

Abstract

Murine Il-6 cDNAs were isolated by cross-hybridization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Cricetinae
  • Cricetulus
  • Crosses, Genetic
  • DNA / isolation & purification
  • Female
  • Genes*
  • Genetic Linkage
  • Interleukin-6
  • Interleukins / genetics*
  • Interleukins / isolation & purification
  • Male
  • Mice
  • Mice, Inbred A
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length
  • Restriction Mapping

Substances

  • Interleukin-6
  • Interleukins
  • DNA

Associated data

  • GENBANK/M24221