Common temporal identity factors regulate neuronal diversity in fly ventral nerve cord and mouse retina

Neuron. 2015 Feb 4;85(3):447-9. doi: 10.1016/j.neuron.2015.01.016.

Abstract

Temporal sequences of transcription factors (tTFs) in Drosophila neural progenitors generate neuronal diversity. Mattar et al. (2015) identify Casz1/Castor as a late temporal identity factor in mouse retinal progenitors that is regulated by the early factor Ikzf1/Hunchback, thus generalizing the notion of tTFs.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / biosynthesis*
  • Drosophila Proteins / biosynthesis*
  • Female
  • Neural Stem Cells / metabolism*
  • Pregnancy
  • Retinal Neurons / metabolism*
  • Transcription Factors / biosynthesis*

Substances

  • CASZ1 protein, human
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Transcription Factors