Management of emerging multidrug-resistant tuberculosis in a low-prevalence setting

Clin Microbiol Infect. 2015 May;21(5):472.e7-10. doi: 10.1016/j.cmi.2014.12.022. Epub 2015 Jan 20.

Abstract

Multidrug-resistant (MDR) tuberculosis (TB) is an emerging concern in communities with a low TB prevalence and a high standard of public health. Twenty-three consecutive adult MDR TB patients who were treated at our institution between 2007 and 2013 were reviewed for demographic characteristics and anti-TB treatment management, which included surgical procedures and long-term patient follow-up. This report of our experience emphasizes the need for an individualized approach as MDR TB brings mycobacterial disease management to a higher level of expertise, and for a balance to be found between international current guidelines and patient-tailored treatment strategies.

Keywords: Bedaquiline; MDR TB surgery; Mycobacterium tuberculosis; multidrug-resistant tuberculosis; negative-pressure ventilation room.

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use
  • Case Management / organization & administration*
  • Communicable Diseases, Emerging / diagnosis*
  • Communicable Diseases, Emerging / drug therapy*
  • Communicable Diseases, Emerging / epidemiology
  • Female
  • Humans
  • Male
  • Precision Medicine / methods
  • Prevalence
  • Retrospective Studies
  • Surgical Procedures, Operative
  • Tuberculosis, Multidrug-Resistant / diagnosis*
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Multidrug-Resistant / therapy*

Substances

  • Antitubercular Agents