Imaging in drug development

Prog Med Chem. 2015:54:231-80. doi: 10.1016/bs.pmch.2014.10.002. Epub 2014 Nov 27.

Abstract

Imaging has played an important part in the diagnosis of disease and development of the understanding of the underlying disease mechanisms and is now poised to make an impact in the development of new pharmaceuticals. This chapter discusses the underlying technologies that make the field ready for this challenge. In particular, the potentials of magnetic resonance imaging and functional magnetic resonance imaging are outlined, including the new methods developed to provide additional information from the scans carried out. The field of nuclear medicine has seen a rapid increase in interest as advances in radiochemistry have enabled a wide range of new radiotracers to be synthesised.

Keywords: Clinical trials; Fluorine-18; Imaging; MRI; PET; Radiochemistry; SPECT.

Publication types

  • Review

MeSH terms

  • Drug Discovery*
  • Magnetic Resonance Imaging / methods*
  • Positron-Emission Tomography / methods*
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Translational Research, Biomedical