Hepatitis B Virus Infection can Cause Hepatocellular Carcinoma in Less Advanced Liver Cirrhosis: A Comparative Study of 142 Patients from North India

Anil Arora; Praveen Sharma; Pankaj Tyagi; Vikas Singla; Veronica Arora; Naresh Bansal; Jay Toshniwal; Ashish Kumar

doi:10.1016/j.jceh.2013.08.007

Hepatitis B Virus Infection can Cause Hepatocellular Carcinoma in Less Advanced Liver Cirrhosis: A Comparative Study of 142 Patients from North India

J Clin Exp Hepatol. 2013 Dec;3(4):288-95. doi: 10.1016/j.jceh.2013.08.007. Epub 2013 Sep 20.

Authors

Anil Arora¹, Praveen Sharma¹, Pankaj Tyagi¹, Vikas Singla¹, Veronica Arora¹, Naresh Bansal¹, Jay Toshniwal¹, Ashish Kumar¹

Affiliation

¹ Department of Gastroenterology & Hepatology, Sir Ganga Ram Hospital, New Delhi 110 060, India.

Abstract

Background and aims: The clinical profile of patients with hepatocellular carcinoma (HCC) may differ depending on the etiology of HCC. There is no study from India comparing the clinical profile of patients of HCC due to hepatitis B virus (HBV) infection with other etiologies.

Methods: We retrospectively reviewed the records of patients clinically diagnosed as HCC between Nov 2000 and Dec 2012 admitted under a single unit of Department of Gastroenterology at our hospital. We compared the clinical presentation of patients of Hepatitis B virus etiology (HBV group) with other etiologies (Non-HBV group).

Results: One hundred and forty-two patients were included (median age 60 years [range 30-83], 92% males). The etiology was HBV in 56 (39%) and among the non-HBV group (n = 86, 61%) the etiological spectrum was following: alcohol 31 (22%), cryptogenic 26 (18%), HCV 27 (19%), and miscellaneous 2 (1%). The median age of presentation was significantly less for HBV group than in non-HBV (56 [30-77] vs. 62 [42-83] years, P < 0.01). Clinical evidence of cirrhosis was significantly less common in the HBV group than non-HBV group (74% vs 98%, P < 0.01). HBV group had lower CTP score than non-HBV (median CTP score 7 vs 8,P < 0.05). Ascites was more common in non-HBV group than HBV group (65% vs 43%, P = 0.018). The BCLC staging was: A 13%, B 23%, C 35%, and D 29%, and there was no difference in tumor characteristics or BCLC staging between HBV or the non-HBV group.

Conclusions: HBV is a common cause of HCC in India, accounting for 39% of cases. The tumor characteristics of HCC due to HBV is similar to other etiologies, however, HBV causes HCC at an earlier age, and in less advanced or even absence of cirrhosis, thus further consolidating the directly carcinogenic potential of HBV.

Keywords: AFP, alpha-fetoprotein; ALT, alanine aminotransferase; BCLC, Barcelona Clinic Liver Cancer; FNAC, fine needle aspiration cytology; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; HIS, hospital information system; carcinogenic; cirrhosis; hepatitis B; hepatocellular carcinoma; liver cancer.