Dopamine D₂/₃ receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [¹¹C]-raclopride PET study

Schizophr Res. 2015 May;164(1-3):263-7. doi: 10.1016/j.schres.2015.02.020. Epub 2015 Mar 8.

Abstract

Background: No study has examined dopamine D₂/₃ receptor (D₂/₃R) availability in antipsychotic-free older patients with schizophrenia.

Methods: We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BPND) of [(11)C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls.

Results: Ten patients participated (antipsychotic-naive=4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72)=.42, p=.52).

Conclusion: The preliminary results suggest no differences in D₂/₃R availability between antipsychotic-free older patients with schizophrenia and controls.

Keywords: Aging; D(2/3) receptor; Dopamine; PET; Schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents / pharmacokinetics*
  • Carbon Isotopes / pharmacokinetics
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / drug effects
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Raclopride / pharmacokinetics*
  • Receptors, Dopamine D2 / metabolism*
  • Schizophrenia / diagnostic imaging*
  • Schizophrenia / pathology*

Substances

  • Antipsychotic Agents
  • Carbon Isotopes
  • Receptors, Dopamine D2
  • Raclopride