Influenza vaccines: challenges and solutions

Cell Host Microbe. 2015 Mar 11;17(3):295-300. doi: 10.1016/j.chom.2015.02.012.

Abstract

Vaccination is the best method for the prevention and control of influenza. Vaccination can reduce illness and lessen severity of infection. This review focuses on how currently licensed influenza vaccines are generated in the U.S., why the biology of influenza poses vaccine challenges, and vaccine approaches on the horizon that address these challenges.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Antigens, Viral / genetics
  • Antigens, Viral / immunology*
  • Humans
  • Influenza Vaccines / immunology*
  • Influenza Vaccines / isolation & purification
  • Influenza, Human / prevention & control*
  • Mutation*
  • Orthomyxoviridae / genetics
  • Orthomyxoviridae / immunology*
  • Orthomyxoviridae / physiology
  • Reassortant Viruses / genetics
  • Reassortant Viruses / immunology*
  • Technology, Pharmaceutical / methods*
  • Technology, Pharmaceutical / trends
  • United States

Substances

  • Antigens, Viral
  • Influenza Vaccines