Abstract
The network hypothesis postulates the existence of internal idiotopic structures which mimic nominal antigens. Experimental evidence for idiotope internal antigen is presented and its implication for the Network hypothesis is discussed. The exploitation of the internal idiotope antigens (or preparation of vaccines) is a realistic possibility.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antibodies / immunology
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Antibodies, Monoclonal / immunology
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Antigens / immunology*
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Epitopes / immunology
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Humans
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Immunity*
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Immunoglobulin Idiotypes / immunology
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Immunoglobulin M / immunology
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Insulin / immunology
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Mice
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Mice, Inbred BALB C
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Rabbits
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Rats
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Trypanosomiasis, African / immunology
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Turkeys / immunology
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Vaccines / immunology
Substances
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Antibodies
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Antibodies, Monoclonal
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Antigens
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Epitopes
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Immunoglobulin Idiotypes
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Immunoglobulin M
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Insulin
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Vaccines