VATS versus intrapleural streptokinase: A prospective, randomized, controlled clinical trial for optimum treatment of post-traumatic Residual Hemothorax

Injury. 2015 Sep;46(9):1749-52. doi: 10.1016/j.injury.2015.02.028. Epub 2015 Mar 12.

Abstract

Background: Post-traumatic residual haemothorax (RH) is common and carries significant morbidity. However, its optimal treatment is not clear.

Aim: The aim of this study was to find the extent of this problem and the choice of treatment between VATS and intra-pleural streptokinase instillation (IPSI).

Material and methods: This RCT, conducted over 18 months period, included all patients of chest trauma between 18 and 70 years of age, admitted with haemothorax or haemopneumothorax requiring inter-costal drain (ICD) insertion. 154 events of haemothorax/haemopneumothorax requiring ICD insertion were enrolled. RH was seen in 48 (31%) patients: 13 patients were excluded from RCT after refusal for treatment. Seventeen (49%) patients of remaining 35 RH cases were randomized to IPSI group and 18 (51%) patients were randomized to VATS group. The outcome parameters were resolution of RH and treatment related complications.

Results: RH resolved equally well in VATS and IPSI group [13 patients (72%) versus 12 patients (71%), respectively; continuity-adjusted p=1]. Morbidity wise no difference (p-value 0.529) was seen in the two groups.

Conclusion: Post-traumatic RH is seen in 1/3rd patients and is equally well treated by VATS and IPSI.

Keywords: Chest trauma; Haemothorax; Intercostal drainage; Intrapleural streptokinase; Residual haemothorax; Retained haemothorax; VATS.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chest Tubes
  • Drainage
  • Female
  • Fibrinolytic Agents / administration & dosage*
  • Hemothorax / drug therapy
  • Hemothorax / etiology
  • Hemothorax / mortality
  • Hemothorax / surgery
  • Hemothorax / therapy*
  • Humans
  • India / epidemiology
  • Length of Stay
  • Male
  • Prospective Studies
  • Streptokinase / administration & dosage*
  • Thoracic Injuries / complications
  • Thoracic Injuries / mortality
  • Thoracic Injuries / therapy*
  • Thoracic Surgery, Video-Assisted*
  • Thrombolytic Therapy*
  • Wounds, Nonpenetrating / complications
  • Wounds, Nonpenetrating / mortality
  • Wounds, Nonpenetrating / therapy*

Substances

  • Fibrinolytic Agents
  • Streptokinase