Criteria for biological reproducibility: what does "n" mean?

Kristen Naegle; Nancy R Gough; Michael B Yaffe

doi:10.1126/scisignal.aab1125

Criteria for biological reproducibility: what does "n" mean?

Sci Signal. 2015 Apr 7;8(371):fs7. doi: 10.1126/scisignal.aab1125.

Authors

Kristen Naegle¹, Nancy R Gough², Michael B Yaffe³

Affiliations

¹ Biomedical Engineering and the Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. myaffe@mit.edu knaegle@wustl.edu.
² Chief Scientific Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
³ David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA. myaffe@mit.edu knaegle@wustl.edu.

PMID: 25852186
DOI: 10.1126/scisignal.aab1125

Abstract

This Focus tackles the issue of technical versus biological replicates, what constitutes appropriate biological replicates, and appropriate statistical analysis for data with small sample sizes.

Publication types

Review

MeSH terms

Animals
Biomedical Research*
Humans
Models, Biological*
Reproducibility of Results*