Predictors of mortality subsequent to a fracture in diabetes mellitus patients

Sidse Westberg-Rasmussen; Jakob Starup-Linde; Søren Gregersen; Peter Vestergaard

doi:10.3389/fendo.2015.00046

Predictors of mortality subsequent to a fracture in diabetes mellitus patients

Front Endocrinol (Lausanne). 2015 Apr 1:6:46. doi: 10.3389/fendo.2015.00046. eCollection 2015.

Authors

Sidse Westberg-Rasmussen¹, Jakob Starup-Linde², Søren Gregersen¹, Peter Vestergaard³

Affiliations

¹ Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Aarhus , Denmark.
² Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Aarhus , Denmark ; Department of Clinical Medicine, Aalborg University , Aalborg , Denmark ; Department of Endocrinology, Aalborg University , Aalborg , Denmark.
³ Department of Clinical Medicine, Aalborg University , Aalborg , Denmark ; Department of Endocrinology, Aalborg University , Aalborg , Denmark.

Abstract

Background: Type-1 and type-2 diabetes mellitus (DM) are associated with an increased fracture risk and possibly an increased risk of death following a fracture.

Aim: To investigate the association between diabetes-related drugs and mortality following a fracture.

Methods: A nested case-control study was conducted. Cases were patients with DM who died following a fracture; controls were DM patients not dying after a fracture. We identified DM patients using the Danish National Hospital Discharge Register (1977-2011) and included information on date of DM diagnosis, date of fracture, and comorbidities. From the Danish Cause of Death Register, the date of death was collected (2008-2011). From the Central Region of Jutland, Denmark, medication use was collected (2008-2011). Analysis was performed by unconditional logistic regression.

Results: Two thousand six hundred twenty one diabetes patients with a fracture following the diabetes diagnosis and with information on medication use were included. Of these, 229 died. In a multivariate analysis, statin use [n = 1,106 (42%) statin users, odds ratio (OR) = 0.60, 95% confidence interval, p = 0.012] decreased the risk of dying subsequent to a fracture. Male gender (OR = 1.57, p = 0.005), increasing age (OR = 1.08, p < 0.001), a diagnosis of retinopathy (OR = 2.12, p = 0.008), heart failure (OR = 1.68, p = 0.004), and use of glucocorticoids (OR = 2.22, p = 0.001) were associated with an increased risk of death. None of the antidiabetics: biguanides, glucagon-like receptor agonists, β-cell stimulants, glitazones, and insulin were associated with mortality.

Conclusion: Co-morbidity reflected by late onset complications, heart failure, and glucocorticoid use was associated with an increased risk of mortality subsequent to a fracture. Statin use may reduce mortality subsequent to a fracture in diabetes patients. Clinical trials are needed to determine whether diabetes patients with a fracture should initiate statin treatment.

Keywords: antidiabetics; diabetes mellitus; fracture; mortality; statins.