Natural evolution of broadly neutralizing antibodies

Galit Alter; Dan H Barouch

doi:10.1016/j.cell.2015.04.007

Natural evolution of broadly neutralizing antibodies

Cell. 2015 Apr 23;161(3):427-428. doi: 10.1016/j.cell.2015.04.007.

Authors

Galit Alter¹, Dan H Barouch²

Affiliations

¹ Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02138, USA.
² Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02138, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address: dbarouch@bidmc.harvard.edu.

Abstract

Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing / genetics*
B-Lymphocytes / immunology*
Evolution, Molecular*
HIV Infections / immunology*
HIV-1 / immunology*
Humans

Substances

Antibodies, Neutralizing

Abstract

Publication types

MeSH terms

Substances

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