Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense

Alexander L Greninger; Charles Langelier; Gail Cunningham; Chris Keh; Michael Melgar; Charles Y Chiu; Steve Miller

doi:10.1128/JCM.00402-15

Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense

J Clin Microbiol. 2015 Jul;53(7):2374-7. doi: 10.1128/JCM.00402-15. Epub 2015 Apr 29.

Authors

Alexander L Greninger¹, Charles Langelier², Gail Cunningham³, Chris Keh², Michael Melgar⁴, Charles Y Chiu⁵, Steve Miller⁶

Affiliations

¹ Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA.
² Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA.
³ Department of Laboratory Medicine, University of California, San Francisco, California, USA.
⁴ Department of Internal Medicine, University of California San Francisco, San Francisco, California, USA.
⁵ Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA.
⁶ Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA Steve.Miller@ucsfmedctr.org.

Abstract

Rapidly growing mycobacteria are rarely found in central nervous system infections. We describe a case of polymicrobial infection in a brain abscess including two rapidly growing Mycobacterium species, M. immunogenum and M. llatzerense. The Mycobacterium isolates were distinguishable by molecular methods, and whole-genome sequencing showed <60% pairwise nucleotide identity.

Publication types

Case Reports

MeSH terms

Adult
Brain Abscess / diagnosis*
Brain Abscess / microbiology
Coinfection / diagnosis
Coinfection / microbiology
Female
Genome, Bacterial*
Head / diagnostic imaging
Humans
Magnetic Resonance Imaging
Molecular Sequence Data
Mycobacterium Infections, Nontuberculous / diagnosis*
Mycobacterium Infections, Nontuberculous / microbiology
Nontuberculous Mycobacteria / classification
Nontuberculous Mycobacteria / genetics*
Nontuberculous Mycobacteria / isolation & purification*
Radiography
Sequence Analysis, DNA*
Sequence Homology, Nucleic Acid

Associated data

GENBANK/JXST00000000
GENBANK/JXUU00000000