A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Y Gocho; N Kiyokawa; H Ichikawa; K Nakabayashi; T Osumi; T Ishibashi; H Ueno; K Terada; K Oboki; H Sakamoto; Y Shioda; M Imai; Y Noguchi; Y Arakawa; Y Kojima; D Toyama; K Hata; T Yoshida; K Matsumoto; M Kato; T Fukushima; K Koh; A Manabe; A Ohara; Tokyo Children’s Cancer Study Group

doi:10.1038/leu.2015.111

A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

Leukemia. 2015 Dec;29(12):2445-8. doi: 10.1038/leu.2015.111. Epub 2015 May 6.

Authors

Y Gocho^{1

2}, N Kiyokawa¹, H Ichikawa³, K Nakabayashi⁴, T Osumi⁵, T Ishibashi^{1

6}, H Ueno¹, K Terada^{1

7}, K Oboki⁸, H Sakamoto³, Y Shioda⁵, M Imai⁹, Y Noguchi⁷, Y Arakawa¹⁰, Y Kojima¹¹, D Toyama¹², K Hata⁴, T Yoshida³, K Matsumoto¹³, M Kato¹⁴, T Fukushima¹⁵, K Koh¹⁰, A Manabe¹⁶, A Ohara¹¹; Tokyo Children’s Cancer Study Group

Affiliations

¹ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
² Department of Pediatrics, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
³ Division of Genetics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
⁴ Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁵ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
⁶ Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
⁷ Department of Pediatrics, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan.
⁸ Department of Molecular Medical Research, Tokyo Metropolitan Institute of Medical Science Setagaya-ku, Tokyo, Japan.
⁹ Department of Pediatrics, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan.
¹⁰ Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
¹¹ Department of Pediatrics, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan.
¹² Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
¹³ Department of Allergy and Immunology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
¹⁴ Department of Pediatrics, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
¹⁵ Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
¹⁶ Department of Pediatrics, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.

PMID: 25943178
DOI: 10.1038/leu.2015.111

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Child
E1A-Associated p300 Protein / genetics*
Female
Gene Fusion*
Humans
Male
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Trans-Activators / genetics*

Substances

Trans-Activators
ZNF384 protein, human
E1A-Associated p300 Protein
EP300 protein, human