Abstract
Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells accumulate in the spleen, where they promote extramedullary hematopoiesis and activate classical dendritic cells. In this review, we focus on the ontogeny and function of IRA B cells in acute and chronic inflammation.
Keywords:
B1a cells; GM-CSF; IL-3; IRA B cells; IgM; innate immunity.
© The Japanese Society for Immunology. 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Atherosclerosis / genetics
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Atherosclerosis / immunology*
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Atherosclerosis / pathology
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B-Lymphocyte Subsets / immunology*
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B-Lymphocyte Subsets / microbiology
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B-Lymphocyte Subsets / pathology
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Cell Lineage / immunology*
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Disease Models, Animal
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Gene Expression Regulation / immunology
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Granulocyte-Macrophage Colony-Stimulating Factor / genetics
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Granulocyte-Macrophage Colony-Stimulating Factor / immunology
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Immunity, Innate*
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Immunoglobulin M / biosynthesis
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Immunoglobulin M / genetics
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Interleukin-3 / genetics
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Interleukin-3 / immunology
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Lung / immunology
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Lung / microbiology
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Lung / pathology
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Mice
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Pneumonia / genetics
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Pneumonia / immunology*
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Pneumonia / microbiology
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Pneumonia / pathology
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Sepsis / genetics
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Sepsis / immunology*
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Sepsis / microbiology
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Sepsis / pathology
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Signal Transduction
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Spleen / immunology
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Spleen / microbiology
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Spleen / pathology
Substances
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IL3 protein, human
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Immunoglobulin M
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Interleukin-3
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Granulocyte-Macrophage Colony-Stimulating Factor