Chronic myelogenous leukemia following radiation therapy for testicular seminoma

Blut. 1989 Dec;59(6):503-4. doi: 10.1007/BF00329496.

Abstract

A 43-year-old man was treated with orchiectomy and radiotherapy for testicular seminoma. Four years later, he developed a typical Philadelphia chromosome positive chronic granulocytic leukemia. Since the patient was not eligible for bone marrow transplantation, he was treated with busulfan. Long term follow-up of patients who received radiotherapy for testicular seminoma is warranted in order to detect possible secondary tumors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Busulfan / therapeutic use
  • Combined Modality Therapy
  • Dysgerminoma / radiotherapy*
  • Dysgerminoma / surgery
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / etiology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Male
  • Orchiectomy
  • Philadelphia Chromosome
  • Radiation Injuries*
  • Testicular Neoplasms / radiotherapy*
  • Testicular Neoplasms / surgery

Substances

  • Busulfan