Abstract
A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Animals
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Chemistry Techniques, Synthetic
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Glycopeptides / chemistry*
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Humans
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Molecular Sequence Data
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Mucin-1 / chemistry*
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N-Acetylneuraminic Acid / chemistry*
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Vaccines, Synthetic / chemistry*
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Vaccines, Synthetic / immunology*
Substances
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Glycopeptides
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Mucin-1
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Vaccines, Synthetic
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N-Acetylneuraminic Acid