Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies

Mayumi Muto; Masahiro Mori; Takaki Hiwasa; Masaki Takiguchi; Yasuo Iwadate; Akiyuki Uzawa; Tomohiko Uchida; Hiroki Masuda; Kazuo Sugimoto; Satoshi Kuwabara

doi:10.1016/j.jneuroim.2015.05.005

Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies

J Neuroimmunol. 2015 Jul 15:284:30-6. doi: 10.1016/j.jneuroim.2015.05.005. Epub 2015 May 6.

Authors

Affiliations

¹ Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
² Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: morim@faculty.chiba-u.jp.
³ Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
⁴ Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

PMID: 26025055
DOI: 10.1016/j.jneuroim.2015.05.005

Abstract

In the pathogenesis of multiple sclerosis (MS), B cell/antibody-related mechanisms have recently received attention. To investigate the role of autoantibody in MS, we performed SEREX which can identify autoantibody cyclopedically. We identified serum antibodies against cytoskeletal protein talin1, and the levels of whom were remarkably higher in 39 MS than 43 normal controls (P < 0.01) and 35 disease controls (P = 0.06), and in MS patients without oligoclonal bands than ones with them. Moreover, we found negative-correlations between serum anti-talin1 antibody and IgG index in MS (P = 0.03). Anti-talin1 antibody exists in MS patients' sera, which may have some protective factor.

Keywords: DDX39 protein; IgG index; Multiple sclerosis; Oligoclonal bands; SEREX; TLN1 protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Autoantibodies / blood*
Brain / pathology
Cell Cycle Proteins / immunology
Cell Cycle Proteins / metabolism
DEAD-box RNA Helicases / immunology
DEAD-box RNA Helicases / metabolism
DNA / metabolism
Disability Evaluation
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intracellular Signaling Peptides and Proteins / immunology
Intracellular Signaling Peptides and Proteins / metabolism
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / blood*
Multiple Sclerosis / pathology
Retrospective Studies
Statistics, Nonparametric
Talin / immunology*

Substances

Autoantibodies
Cell Cycle Proteins
Intracellular Signaling Peptides and Proteins
N-myc downstream-regulated gene 1 protein
TLN1 protein, human
Talin
DNA
DDX39A protein, human
DEAD-box RNA Helicases