Abstract
A novel GII.P17-GII.17 variant norovirus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan. Named Hu/GII/JP/2014/GII.P17-GII.17, this variant has a newly identified GII.P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites. Several variants caused by mutations in the capsid region have previously been observed in the GII.4 genotype. Monitoring the GII.17 variant's geographical spread and evolution is important.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution / genetics*
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Caliciviridae Infections / epidemiology
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Caliciviridae Infections / genetics*
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Capsid Proteins / genetics
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Disease Outbreaks*
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Dysentery / epidemiology
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Dysentery / genetics*
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Feces / virology
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Genotype
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Humans
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Japan / epidemiology
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Norovirus / classification*
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Norovirus / genetics*
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Norovirus / isolation & purification
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RNA, Viral / genetics
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RNA-Dependent RNA Polymerase / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Analysis, DNA
Substances
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Capsid Proteins
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RNA, Viral
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RNA-Dependent RNA Polymerase