Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency

Katka Szilagyi; Roel P Gazendam; John L van Hamme; Anton T J Tool; Michel van Houdt; Wilhelm A J W Vos; Paul Verkuijlen; Hans Janssen; Alexandre Belot; Laurent Juillard; Elisabeth Förster-Waldl; Kaan Boztug; Georg Kraal; Menno P J de Winther; Taco W Kuijpers; Timo K van den Berg

doi:10.1016/j.jaci.2015.06.016

Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency

J Allergy Clin Immunol. 2015 Nov;136(5):1404-7.e1-10. doi: 10.1016/j.jaci.2015.06.016. Epub 2015 Jul 30.

Authors

Katka Szilagyi¹, Roel P Gazendam², John L van Hamme³, Anton T J Tool³, Michel van Houdt³, Wilhelm A J W Vos³, Paul Verkuijlen³, Hans Janssen⁴, Alexandre Belot⁵, Laurent Juillard⁶, Elisabeth Förster-Waldl⁷, Kaan Boztug⁸, Georg Kraal⁹, Menno P J de Winther¹⁰, Taco W Kuijpers¹¹, Timo K van den Berg³

Affiliations

¹ Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: k.szilagyi@sanquin.nl.
² Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: r.gazendam@sanquin.nl.
³ Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁴ Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁵ Hôpital Femme Mère Enfant, Hospices Civils de Lyon and Université de Lyon, Lyon, France.
⁶ CarMen U1060 Université de Lyon, Lyon, France; Service de Néphrologie, H. E. Herriot Hospices Civils de Lyon, Lyon, France.
⁷ Divison of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
⁸ Divison of Neonatology, Paediatric Intensive Care & Neuropaediatrics, Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
⁹ Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
¹⁰ Department of Medical Biochemistry, Experimental Vascular Biology, Academic Medical Center, Amsterdam, The Netherlands.
¹¹ Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Pediatric Hematology, Immunology and Infectious Disease, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 26233929
DOI: 10.1016/j.jaci.2015.06.016

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anti-Infective Agents / immunology
Anti-Infective Agents / metabolism*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology*
Cytoplasmic Granules / immunology
Cytoplasmic Granules / metabolism*
Cytotoxicity, Immunologic*
Female
Humans
Infections / genetics
Infections / immunology*
Male
Mutation / genetics
NADP / metabolism
Neutrophils / immunology*
Protein Kinase C-delta / deficiency*
Protein Kinase C-delta / genetics
Reactive Oxygen Species / metabolism
Recurrence
Young Adult

Substances

Anti-Infective Agents
Reactive Oxygen Species
NADP
Protein Kinase C-delta