Infections on the rise: Raoultella spp., clinical and microbiological findings from a retrospective study, 2010-2014

Infect Dis (Lond). 2016;48(1):87-91. doi: 10.3109/23744235.2015.1082619. Epub 2015 Sep 11.

Abstract

We performed a retrospective analysis of clinical and laboratory data over 5 years in a tertiary centre to assess clinical and microbiological characteristics of patients with Raoultella spp. infection. Raoultella spp. were deemed responsible for clinical infections in 57 patients (R. planticola, n = 32 and R. ornithinolytica, n = 25). The most prevalent diagnoses for R. planticola were cystitis (50%; n = 16) followed by bacteraemia and pneumonia (9.4%; n = 3); for R. ornithinolytica, cystitis (36%; n = 9) followed by pneumonia (24%; n = 6). Immunodeficiency was present in 18 patients (56.3%) with R. planticola and in 16 patients (64%) with R. ornithinolytica infection. Of these, 55.6% and 37.5% had diabetes and 27.8% and 18.% were solid organ transplant recipients, respectively. All isolates were sensitive to third-generation cephalosporins, fluoroquinolones and aminoglycosides. Mortality of infections with R. planticola (n = 5; 15.6%) was higher than for R. ornithinolytica (n = 2; 8.0%), but the difference was not statistically significant.

Keywords: Enterobacteriaceae; Raoultella; gram-negative; infection; multiple drug resistance.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / etiology
  • Cystitis / microbiology
  • Diabetes Complications / microbiology
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / isolation & purification*
  • Enterobacteriaceae Infections / diagnosis*
  • Enterobacteriaceae Infections / epidemiology
  • Enterobacteriaceae Infections / microbiology*
  • Enterobacteriaceae Infections / mortality
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia, Bacterial / microbiology
  • Portugal / epidemiology
  • Retrospective Studies
  • Tertiary Care Centers*
  • Time Factors
  • Transplant Recipients

Substances

  • Anti-Bacterial Agents