The microbiome, HLA, and the pathogenesis of uveitis

Jpn J Ophthalmol. 2016 Jan;60(1):1-6. doi: 10.1007/s10384-015-0416-y. Epub 2015 Sep 14.

Abstract

An understanding of the microbiome is emerging as an exciting and novel way to elucidate the regulation of the immune system. Since the immune system plays a major role in the pathogenesis of many diseases including most forms of uveitis, it is critical to clarify the relationship between our immune system and the commensal bacteria that coexist in every human being.

Keywords: Ankylosing spondylitis; HLA; Iritis; Microbiome; Uveitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • HLA Antigens / immunology*
  • Humans
  • Immune System / physiology
  • Microbiota / physiology*
  • Uveitis / immunology*

Substances

  • HLA Antigens