miR-155 releases the brakes on antitumor T cells

Yun Ji; Luca Gattinoni

doi:10.1080/2162402X.2015.1026533

miR-155 releases the brakes on antitumor T cells

Oncoimmunology. 2015 Jun 3;4(8):e1026533. doi: 10.1080/2162402X.2015.1026533. eCollection 2015 Aug.

Authors

Yun Ji¹, Luca Gattinoni¹

Affiliation

¹ Experimental Transplantation and Immunology Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda, MD USA.

Abstract

Homeostatic γ_C cytokines are essential to support the expansion and function of tumor-specific T cells, but their effects are constrained by suppressor of cytokine signaling (SOCS) proteins as well as phosphoinositide and tyrosine-specific phosphatases. The microRNA miR-155 counteracts these inhibitory hurdles to potentiate intracellular cytokine signaling and T cell antitumor immunity.

Keywords: Ptpn2; SHIP-1; SOCS-1; adoptive immunotherapy; homeostatic γC cytokines; lymphodepletion; miR-155.