Daptomycin Use in United States Children's Hospitals

J Pediatric Infect Dis Soc. 2015 Mar;4(1):60-2. doi: 10.1093/jpids/piu052. Epub 2014 Jun 2.

Abstract

We described 1035 pediatric hospitalizations with daptomycin use in 794 patients since 2004. Daptomycin use was uncommon but increased over time. A minority of hospitals accounted for the majority of use. This variability of daptomycin use highlights the need for future studies to assess the efficacy and safety of daptomycin in children.

Keywords: MRSA; VRE; children; daptomycin; resistance.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Daptomycin / adverse effects
  • Daptomycin / therapeutic use*
  • Female
  • Hospitals, Pediatric / statistics & numerical data*
  • Humans
  • Infant
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Retrospective Studies
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / epidemiology
  • Tertiary Care Centers / statistics & numerical data
  • United States / epidemiology

Substances

  • Anti-Bacterial Agents
  • Daptomycin