Keeping Off the Weight with DCs

Immunity. 2015 Oct 20;43(4):624-6. doi: 10.1016/j.immuni.2015.10.003.

Abstract

Long studied as modulators of insulin sensitivity, adipose tissue immune cells have recently been implicated in regulating fat mass and weight gain. In this issue of Immunity, Reisner and colleagues (2015) report that ablation of perforin-expressing dendritic cells induces T cell expansion, worsening autoimmunity and surprisingly increasing adiposity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Dendritic Cells / immunology*
  • Female
  • Inflammation / immunology*
  • Male
  • Metabolic Syndrome / immunology*
  • Pore Forming Cytotoxic Proteins / analysis*

Substances

  • Pore Forming Cytotoxic Proteins