Abstract
Neutralization breadth is thought to be an important feature of an effective vaccine against HIV-1. A study in one individual has now identified the specific viral variant that engaged the necessary antibody precursor, as well as the viral immunotypes that drove neutralization breadth, improving understanding of how to mimic this process with a vaccine.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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AIDS Vaccines / immunology*
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Antibodies, Neutralizing / immunology*
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B-Lymphocytes / immunology*
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HIV Antibodies / immunology*
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HIV-1 / immunology*
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High-Throughput Nucleotide Sequencing
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Humans
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Superinfection / immunology
Substances
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AIDS Vaccines
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Antibodies, Neutralizing
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HIV Antibodies