Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC)

Etienne Becht; Nicolas A Giraldo; Benoit Beuselinck; Sylvie Job; Laetitia Marisa; Yann Vano; Stéphane Oudard; Jessica Zucman-Rossi; Pierre Laurent-Puig; Catherine Sautès-Fridman; Aurélien de Reyniès; Wolf Herman Fridman

doi:10.1080/2162402X.2015.1049804

Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC)

Oncoimmunology. 2015 Aug 7;4(12):e1049804. doi: 10.1080/2162402X.2015.1049804. eCollection 2015 Dec.

Affiliations

¹ INSERM UMR_S 1138 Cancer; Immune Control and Escape; Cordeliers Research Centre ; Paris, France ; Université Paris Descartes; Sorbonne Paris Cité; UMR_S 1338; Cordeliers Research Centre ; Paris, France ; Sorbonne Universités; UPMC Univ Paris 06; UMR_S 1138; Cordeliers Research Centre ; Paris, France.
² INSERM; UMR-1162; Génomique fonctionnelle des tumeurs solides ; Paris, France ; University Hospitals Leuven; KULeuven ; Leuven, Belgium.
³ Programme Cartes d'Identité des Tumeurs; Ligue Nationale Contre le Cancer ; Paris, France.
⁴ INSERM UMR_S 1138 Cancer; Immune Control and Escape; Cordeliers Research Centre ; Paris, France ; Université Paris Descartes; Sorbonne Paris Cité; UMR_S 1338; Cordeliers Research Centre ; Paris, France ; Sorbonne Universités; UPMC Univ Paris 06; UMR_S 1138; Cordeliers Research Centre ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Oncology , Paris, France.
⁵ Université Paris Descartes; Sorbonne Paris Cité; UMR_S 1338; Cordeliers Research Centre ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Oncology , Paris, France.
⁶ INSERM; UMR-1162; Génomique fonctionnelle des tumeurs solides ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Oncology , Paris, France.
⁷ Université Paris Descartes; Sorbonne Paris Cite; INSERM, UMR-S1147 ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Biology , Paris, France.
⁸ INSERM UMR_S 1138 Cancer; Immune Control and Escape; Cordeliers Research Centre ; Paris, France ; Université Paris Descartes; Sorbonne Paris Cité; UMR_S 1338; Cordeliers Research Centre ; Paris, France ; Sorbonne Universités; UPMC Univ Paris 06; UMR_S 1138; Cordeliers Research Centre ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Biology , Paris, France.

Abstract

Molecular and immune classifications powerfully predict cancer patient's survival and response to therapies. We herein describe the immune tumor microenvironment of molecular subgroups of colorectal and renal cell cancers, revealing a strong correlation between tumor subtypes and distinct immune profiles.

Keywords: Cancer molecular subtypes; colorectal cancer; immune classification; prognostic and theranostic markers; renal cell cancer; tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't