Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity

Xiaoyu Wang; Caijun Sun; Pingchao Li; Tongjin Wu; Hangyu Zhou; Dong Yang; Yichu Liu; Xiuchang Ma; Zhiyong Song; Qinggong Nian; Liqiang Feng; Chengfeng Qin; Ling Chen; Ruikang Tang

doi:10.1002/adma.201503740

Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity

Adv Mater. 2016 Jan 27;28(4):694-700. doi: 10.1002/adma.201503740. Epub 2015 Nov 26.

Authors

Xiaoyu Wang¹, Caijun Sun², Pingchao Li², Tongjin Wu², Hangyu Zhou³, Dong Yang⁴, Yichu Liu², Xiuchang Ma², Zhiyong Song³, Qinggong Nian⁴, Liqiang Feng², Chengfeng Qin⁴, Ling Chen^{2

5}, Ruikang Tang^{1

3

6}

Affiliations

¹ Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
² State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, P. R. China.
³ Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
⁴ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China.
⁵ State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P. R. China.
⁶ State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, 310027, P.R. China.

PMID: 26607212
DOI: 10.1002/adma.201503740

Abstract

Dual-functional biomineral-vaccine core-shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently masks the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti-Ad5 immunity, leading to boosted multifunctional antigen-specific cytokine-secreting T cell responses and presenting promising applications of vaccine-material hybrid for the rational design of vaccines.

Keywords: T cells; adenovirus; calcium phosphate; preexisting immunity; vaccine engineering.