Background: Whether smokers and former smokers have worse lipid profiles or glucose levels than non-smokers remains unclear.
Methods: The subjects were 1152 Japanese males aged 42 to 81 years. The subjects were divided according to their smoking habits (nonsmokers, former smokers, and current smokers) and their visceral fat area (VFA) (<100 cm(2) and ≥100 cm(2)).
Results: The serum triglyceride (TG) levels of 835 males were assessed. In the VFA ≥100 cm(2) group, a significantly greater proportion of current smokers (47.3%) exhibited TG levels of ≥150 mg/dL compared with former smokers (36.4%) and non-smokers (18.8%). The difference in TG level distribution between former smokers and non-smokers was also significant. However, among the subjects with VFA of <100 cm(2), the TG levels of the three smoking habit groups did not differ. The serum hemoglobin A1c (HbA1c) levels of 877 males were also assessed. In the VFA <100 cm(2) group, significantly higher proportions of current smokers (17.9%) and former smokers (14.9%) demonstrated HbA1c levels of ≥5.6% compared with non-smokers (6.3%). In contrast, in the VFA ≥100 cm(2) group, significantly fewer former smokers displayed HbA1c levels of ≥5.6% compared with non-smokers and current smokers. Furthermore, the interaction between smoking habits and VFA was associated with the subjects' TG and HbA1c concentrations, and the associations of TG and HbA1c concentrations and smoking habits varied according to VFA.
Conclusions: Both smoking habits and VFA exhibited associations with TG and HbA1c concentrations. The associations between smoking habits and these parameters differed according to VFA.
背景：: 喫煙者や禁煙者は、脂質状態や血糖値に関して非喫煙者よりも好ましくない状態にあるかどうか依然として明確ではない。
方法：: 対象者は42-81歳の日本人男性1152名であった。対象者を喫煙習慣（非喫煙、禁煙、喫煙の3群）で分け、さらに内臓脂肪面積（VFA）（100cm2未満群と100cm2以上群）で分割した。
結果：: 血清中性脂肪（TG）値について835名で検討した。VFA100cm2 以上では、喫煙群のTG150mg/dL以上の人の割合（47.3%）は、禁煙群（36.4%）や非喫煙群（18.8%）と比較して有意に高かった。禁煙群と非喫煙群間においてもTG値の分布は有意に異なっていた。しかし、VFA100 cm2未満では、3群間で違いは認められなかった。血清ヘモグロビンA1c（HbA1c）値に関しても877名で同様に検討した。VFA100 cm2未満では、喫煙群（17.9%）と禁煙群（14.9%）のHbA1c5.6%以上の人の割合は、非喫煙群（6.3%）と比較して有意に高かった。反対に、VFA100 cm2 以上では、それらの割合は非喫煙群や喫煙群よりも禁煙群で有意に低かった。また、喫煙習慣とVFAとの交互作用はTG値およびHbA1c値でともにみられたが、TG値やHbA1c値と喫煙習慣との関係はVFAによって異なっていた。
結論：: 喫煙もVFAもそれぞれTG値やHbA1c値と関係することが認められた。喫煙習慣とそれらとの関係はVFAの大小によって異なっていた。