Abstract
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the list of common causes of mortality after cardiovascular diseases. The processes of atherogenesis and cardiovascular diseases are accelerated in patients with COPD. The key mechanisms of COPD pathogenesis are oxidative stress, depletion of antioxidant protection, development of the pulmonary and systemic inflammation and the development of endothelial dysfunction. This article discusses the pleiotropic effects of statins in patients with COPD.
MeSH terms
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Cardiovascular Diseases / complications
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Cardiovascular Diseases / epidemiology*
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / prevention & control
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Dose-Response Relationship, Drug
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Female
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Follow-Up Studies
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
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Incidence
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Male
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Middle Aged
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Oxidative Stress / drug effects
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Pulmonary Disease, Chronic Obstructive / complications
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Pulmonary Disease, Chronic Obstructive / drug therapy*
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Pulmonary Disease, Chronic Obstructive / metabolism
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Retrospective Studies
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Risk Factors
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Rosuvastatin Calcium / administration & dosage*
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Russia / epidemiology
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Treatment Outcome
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Rosuvastatin Calcium