Abstract
In this issue of Blood, Yu et al describe a novel anti–Fcγ receptor III (FcγRIII)-albumin fusion protein that inhibits the development of thrombocytopenia in a murine model of immune thrombocytopenia (ITP).1 The unique aspect of this protein is that it blocks FcγRIII-mediated uptake of antibody-coated platelets without activating FcγRIII and the associated inflammatory response.
MeSH terms
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Albumins / immunology*
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Animals
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Antibodies, Monoclonal / pharmacology*
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Female
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Humans
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Immunoglobulin Fc Fragments / immunology*
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Purpura, Thrombocytopenic, Idiopathic / therapy*
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Receptors, IgG / antagonists & inhibitors*
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Receptors, IgG / immunology*
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Recombinant Fusion Proteins / immunology*
Substances
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Albumins
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Antibodies, Monoclonal
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Immunoglobulin Fc Fragments
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Receptors, IgG
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Recombinant Fusion Proteins