Proton Pump Inhibitor Prophylaxis After Gastric Bypass Does Not Cause Hypomagnesemia

Obes Surg. 2016 Mar;26(3):688-90. doi: 10.1007/s11695-015-2020-0.

Abstract

Proton pump inhibitor (PPI)-induced hypomagnesemia is currently a major topic. Patients undergoing Roux-en-Y gastric bypass are generally prescribed PPI prophylaxis after surgery. We investigated the prevalence of hypomagnesemia in our bariatric population. We reviewed the files of 1000 postoperative patients for serum magnesium level during PPI use. We found only five cases of hypomagnesemia, none of which was evidently related to PPI use. We conclude that the risk of hypomagnesemia during 1 year of prophylactic PPI use after Roux-en-Y gastric bypass (RYGB) is minimal and laboratory screening is probably not necessary.

Keywords: Gastric bypass; Hypomagnesemia; Proton pump inhibitor.

MeSH terms

  • Adult
  • Female
  • Gastric Bypass / adverse effects*
  • Humans
  • Magnesium / blood*
  • Male
  • Middle Aged
  • Obesity, Morbid / blood
  • Obesity, Morbid / surgery*
  • Proton Pump Inhibitors / adverse effects*
  • Proton Pump Inhibitors / therapeutic use

Substances

  • Proton Pump Inhibitors
  • Magnesium