A 4-midable Connection: CCR7 Tetramers Link GPCR to Src Kinase Signaling

Reinhold Förster; Tim Worbs; Kathrin Werth

doi:10.1016/j.immuni.2015.12.009

A 4-midable Connection: CCR7 Tetramers Link GPCR to Src Kinase Signaling

Immunity. 2016 Jan 19;44(1):9-11. doi: 10.1016/j.immuni.2015.12.009.

Authors

Reinhold Förster¹, Tim Worbs², Kathrin Werth²

Affiliations

¹ Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany. Electronic address: foerster.reinhold@mh-hannover.de.
² Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.

PMID: 26789916
DOI: 10.1016/j.immuni.2015.12.009

Abstract

Chemokine receptors are known to signal through heterotrimeric G proteins. In this issue, Hauser et al. (2016) report that inflammatory cues can induce tetramers of the chemokine receptor CCR7 that serve as scaffolds integrating G protein with Src kinase signaling.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chemotaxis / immunology*
Humans
Inflammation / immunology*
Leukocytes, Mononuclear / immunology*
Receptors, CCR7 / immunology*
Signal Transduction / immunology*

Substances

Receptors, CCR7