Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021

J Acquir Immune Defic Syndr. 2016 Aug 1;72(4):372-5. doi: 10.1097/QAI.0000000000000953.

Abstract

Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than females. Of 11 biomarkers assessed by sex and HIV-status, HIV-infected males had increased levels of soluble CD14 which inversely correlated with bone mineral content and bone mineral density measures, suggesting macrophage activation as a possible mechanism of differential bone loss.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adolescent
  • Adult
  • Antiretroviral Therapy, Highly Active* / adverse effects
  • Bone Density / drug effects*
  • Bone Diseases, Metabolic / diagnostic imaging
  • Bone Diseases, Metabolic / physiopathology*
  • Bone Diseases, Metabolic / virology
  • Cross-Sectional Studies
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / physiopathology*
  • Humans
  • Macrophage Activation*
  • Male
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / physiopathology*
  • Osteoporosis / virology
  • Puerto Rico / epidemiology
  • Sex Factors
  • Spine / pathology*
  • United States / epidemiology
  • Young Adult