Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy

J Pediatric Infect Dis Soc. 2016 Jun;5(2):e9-e12. doi: 10.1093/jpids/piw001. Epub 2016 Mar 24.

Abstract

Therapeutics blocking the activity of tumor necrosis factor (anti-TNF) are a risk factor for invasive fungal infections; however, infectious risks to infants born to mothers receiving anti-TNF therapy are not well defined. We report a case of vertical transmission of disseminated histoplasmosis in a mother-infant pair exposed to anti-TNF therapy.

Keywords: histoplasmosis; immunocompromised host; infant; tumor necrosis factor; vertical transmission.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Histoplasmosis / transmission*
  • Humans
  • Infectious Disease Transmission, Vertical*
  • Inflammatory Bowel Diseases / drug therapy
  • Infliximab / adverse effects*
  • Infliximab / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Risk Factors
  • Tumor Necrosis Factor-alpha / administration & dosage*

Substances

  • Tumor Necrosis Factor-alpha
  • Infliximab