Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

Abstract

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor-β (TGF-β) signaling have high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epithelial tension and shorter patient survival. In several KRAS-driven mouse models, both the loss of TGF-β signaling and elevated β1-integrin mechanosignaling engaged a positive feedback loop whereby STAT3 signaling promotes tumor progression by increasing matricellular fibrosis and tissue tension. In contrast, epithelial STAT3 ablation attenuated tumor progression by reducing the stromal stiffening and epithelial contractility induced by loss of TGF-β signaling. In PDAC patient biopsies, higher matricellular protein and activated STAT3 were associated with SMAD4 mutation and shorter survival. The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.

MeSH terms

  • Animals
  • Carcinoma, Pancreatic Ductal / genetics*
  • Carcinoma, Pancreatic Ductal / mortality
  • Carcinoma, Pancreatic Ductal / pathology
  • Chromatography, Liquid
  • Collagen / metabolism
  • Disease Models, Animal
  • Disease Progression
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix / pathology
  • Fibrosis
  • Genotype
  • Humans
  • Integrin beta Chains / metabolism*
  • Mice
  • Microscopy, Atomic Force
  • Mutation
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Prognosis
  • Proteomics
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Real-Time Polymerase Chain Reaction
  • STAT3 Transcription Factor / metabolism*
  • Signal Transduction
  • Smad4 Protein / genetics
  • Survival Rate
  • Tandem Mass Spectrometry
  • Transforming Growth Factor beta / metabolism*
  • Tumor Microenvironment

Substances

  • Integrin beta Chains
  • SMAD4 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Smad4 Protein
  • Stat3 protein, mouse
  • Transforming Growth Factor beta
  • Collagen
  • Hras protein, mouse
  • Proto-Oncogene Proteins p21(ras)