Reduced serologic sensitivity to influenza A virus illness among inactivated influenza vaccinees

Vaccine. 2016 Jun 24;34(30):3443-6. doi: 10.1016/j.vaccine.2016.04.085. Epub 2016 May 16.

Abstract

We compared ≥4-fold increases in antibody titers by hemagglutination inhibition assay to RT-PCR results among 42 adults with PCR-confirmed influenza A virus illnesses. Serologic sensitivity was higher among unvaccinated (69%, 95% confidence interval [CI]=48-90%) than vaccinated healthcare personnel (38%, 95% CI=29-46%) in a 2010-11 prospective cohort.

Keywords: Antibody; Hemagglutinin inhibition; Immunogenicity; Influenza; Influenza vaccine; Seroconversion; Vaccine failure.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Viral / blood*
  • Female
  • Health Personnel
  • Hemagglutination Inhibition Tests
  • Humans
  • Influenza A Virus, H3N2 Subtype
  • Influenza A virus
  • Influenza Vaccines / therapeutic use*
  • Influenza, Human / prevention & control*
  • Linear Models
  • Male
  • Prospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Vaccines, Inactivated / therapeutic use

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, Inactivated