Clinical isolates of uropathogenic Escherichia coli ST131 producing NDM-7 metallo-β-lactamase in China

Lian-Hui Wang; Pan-Pan Liu; Dan-Dan Wei; Yang Liu; La-Gen Wan; Tian-Xin Xiang; Yu-Juan Zhang

doi:10.1016/j.ijantimicag.2016.03.009

Clinical isolates of uropathogenic Escherichia coli ST131 producing NDM-7 metallo-β-lactamase in China

Int J Antimicrob Agents. 2016 Jul;48(1):41-45. doi: 10.1016/j.ijantimicag.2016.03.009. Epub 2016 Apr 22.

Authors

Lian-Hui Wang¹, Pan-Pan Liu¹, Dan-Dan Wei¹, Yang Liu², La-Gen Wan¹, Tian-Xin Xiang³, Yu-Juan Zhang⁴

Affiliations

¹ Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
² Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China. Electronic address: ly13767160474@sina.com.
³ Department of Infection Disease, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
⁴ Institute of Immunotherapy and College of Basic Medicine, Jiangxi Academy of Medical Sciences, Nanchang University, Ba Yi Road No. 603, Nanchang 330006, China.

PMID: 27216384
DOI: 10.1016/j.ijantimicag.2016.03.009

Abstract

Here we report five cases of NDM-7-producing Escherichia coli from patients with bacteriuria in a teaching hospital in mainland China. Two isolates belonged to sequence type 131 (ST131), simultaneously carrying blaCTX-M-15, blaSHV-11, blaTEM-1 and qnrS1. The blaNDM-7 gene was located on a conjugative IncX3-type plasmid bearing blaTEM-1 and qnrS1. These findings indicate the spread of NDM-7 metallo-β-lactamase in a highly resistant and virulent E. coli sequence type in China.

Keywords: Escherichia coli; MLST; Metallo-β-lactamase; Virulent.

MeSH terms

Aged
Bacteriuria / microbiology*
China
Escherichia coli Infections / microbiology*
Female
Genotype
Hospitals, Teaching
Humans
Male
Middle Aged
Multilocus Sequence Typing
Uropathogenic Escherichia coli / classification
Uropathogenic Escherichia coli / enzymology*
Uropathogenic Escherichia coli / genetics
Uropathogenic Escherichia coli / isolation & purification
beta-Lactamases / metabolism*

Substances

beta-Lactamases
beta-lactamase NDM-1