Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Thierry Calandra; Jason A Roberts; Massimo Antonelli; Matteo Bassetti; Jean-Louis Vincent

doi:10.1186/s13054-016-1313-6

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Crit Care. 2016 May 27;20(1):125. doi: 10.1186/s13054-016-1313-6.

Authors

Thierry Calandra¹, Jason A Roberts², Massimo Antonelli³, Matteo Bassetti⁴, Jean-Louis Vincent⁵

Affiliations

¹ Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
² Burns, Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women's Hospital, Butterfield Street, 4029 Herston, Brisbane, Australia.
³ Department of Anesthesiology and Intensive Care Medicine, Catholic University of Rome, A. Gemelli University Hospital, Largo A. Gemelli 8, 00168, Rome, Italy.
⁴ Infectious Diseases Division, Santa Maria Misericordia University Hospital, Piazzale Santa MAria della Misericordia 15, 33100, Udine, Italy.
⁵ Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. jlvincent@intensive.org.

Abstract

Invasive fungal infections, particularly those caused by Candida species, are not uncommon in critically ill patients and are associated with considerable morbidity and mortality. Diagnosis and management of these infections can be challenging. In this review, we will briefly discuss recent epidemiological data on invasive candidiasis and current diagnostic approaches before concentrating on antifungal treatments.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antifungal Agents / pharmacology
Antifungal Agents / therapeutic use*
Candida albicans / pathogenicity
Candidiasis / diagnosis
Candidiasis / drug therapy*
Disease Management*
Fluconazole / pharmacology
Fluconazole / therapeutic use
Humans
Intensive Care Units*
Triazoles / pharmacology
Triazoles / therapeutic use

Substances

Antifungal Agents
Triazoles
Fluconazole