The interaction of cultural consonance and a polymorphism in the 2A serotonin receptor in relation to depression in Brazil: failure to replicate previous findings

Am J Hum Biol. 2016 Nov;28(6):936-940. doi: 10.1002/ajhb.22875. Epub 2016 May 30.

Abstract

Objectives: To replicate a previously identified gene-environment interaction between a genetic polymorphism in the serotonin 2A receptor and cultural consonance in family life in relation to depressive symptoms (Dressler et al., 2009).

Methods: A sample of 402 individuals in a sample drawn from four different economic strata in Ribeirão Preto, Brazil was interviewed and genotyped.

Results: Cultural consonance in family life has an inverse association with depressive symptoms (beta = -0.439, P < 0.001) and with high depressive symptoms (OR = 2.36, P < 0.001), but the interaction with genotype was not statistically significant.

Conclusion: The previously identified gene-environment interaction was not replicated. Limitations of the study are discussed. Am. J. Hum. Biol. 28:936-940, 2016. © 2016Wiley Periodicals, Inc.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Brazil / epidemiology
  • Depression / epidemiology
  • Depression / genetics*
  • Female
  • Gene-Environment Interaction*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Social Environment*

Substances

  • Receptor, Serotonin, 5-HT2A