AOM/DSS Model of Colitis-Associated Cancer

Methods Mol Biol. 2016:1422:297-307. doi: 10.1007/978-1-4939-3603-8_26.

Abstract

Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.

Keywords: AOM; Colitis-associated cancer; Colon cancer; DSS; Inflammatory carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Azoxymethane*
  • Colitis / chemically induced*
  • Colitis / complications
  • Colitis / pathology*
  • Colorectal Neoplasms / chemically induced*
  • Colorectal Neoplasms / pathology*
  • Dextran Sulfate*
  • Disease Models, Animal*
  • Humans
  • Mice

Substances

  • Dextran Sulfate
  • Azoxymethane