Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis

Tie Wang; Lining Tian; Meizhuo Gao; Hongjiang Song; Yuzhe Wei; Yingwei Xue

doi:10.1016/j.amsu.2016.05.011

Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis

Ann Med Surg (Lond). 2016 May 18:9:1-5. doi: 10.1016/j.amsu.2016.05.011. eCollection 2016 Aug.

Authors

Tie Wang¹, Lining Tian², Meizhuo Gao³, Hongjiang Song¹, Yuzhe Wei¹, Yingwei Xue¹

Affiliations

¹ Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
² Department of Medical Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
³ Department of General Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Abstract

Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and gastric cancer has been studied in different populations with inconsistent results. Here, we report this meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC susceptibility in both Asian and Caucasian populations.

Keywords: Gastric cancer; Interleukin-4; Meta-analysis; Polymorphism; Susceptibility.

Publication types

Review